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Genetics-History-Mendel | Notes-by-UK-Sir | Genetics-1


Genetics (Heredity and variation )

Chromosome
Chromosome


 Genetics:

Definition:

-          The study of heredity and variation may be called as Genetics.

-          Or

-          The branch of science deals with the study of Heredity and variation may be called as Genetics.

-          or  

    The detail study of all aspects of gene like structure, composition, transformation, function and behavior.

-          Genetics term was introduced by Bateson (1905)

-          Heredity – transfer of character from parent to off springs ( transformation of gene from one generation to another cause similarity )

-          Variation- The dissimilarity (different character)  between parent and off springs.

 

Branches of Genetics

-          1)Classical genetics

-          2)Molecular genetics

-          3)Evolutionary genetics

-          4)Applied genetics

 

History:

-          Hippocrates – 1st time called reproductive material as “Gonos” (means seeds)

-          Koelreuter (1760)- 1st time carried out breeding experiment in tobacco plant.

-          T.A. Knight  (1790 )- Crossed two varieties of garden Pea plant and concluded that some characters are more numerous then others.

-          John Goss- (1822) – crossed pea plants and found that a parental character reappears in off springs.

-          Charles Darwin (1868)- there are microscopic granules pass directly to the off springs from parent cell – named as Gemmule.

-          Gregor johann Mendel (1865-66)- 1st time explained details of genetics. (Called as father of genetics)

T.H. Morgan


-          T.H. Morgan (1910)- genes reside on specific chromosomes. Genes occupy specific locations on the chromosome.

 Hugo de Vries (Holland)-  He republished Mendel's results in 1901 in Flora magazine

-          W. Bateson- Father of Modern Genetics

-          Morgan – Father of Experimental genetics

-          A. Garrod – Father of Biochemical and Human genetics.

 

Terminology:


Factor : or gene

-          The entity responsible for inheritance of character or trait. Or inherited factor which determine the biological character of an organism.

     Also Named as Unit factor by Mendel.

-          The basic unit of inheritance of character.

Gene term coined by Johannse 1909.

Genes:                    

-            (Molecular biology) Functional part of DNA.

Alleles:

-          Alternative form of same gene for contrasting characters, located on same position (Locus) on homologous chromosome. (Tall vs dwarf) Term given by Bateson.

Contrasting Character:

-          Remarkable / observable feature for phenotype/ character which can show clear cut difference (Red vs white)

Phenotype:

-          Physical or external- observed or appeared character (traits)

-          Ex- Tall, dwarf, Red, white etc. Phenotype and genotype term was given by Johannsen (1909).

Genotype:

-          Genetic expression of a character in term of alleles with a symbol (e.g – TT, RR, Tt, Rr, rr etc)

Phenocopy :

It’s a variation of Phenotype. If different Genotype placed in different environmental conditions, they produce same phenotype. Which can be called as Phenocopy.

Dominant : (T, R, W etc)

-          The character/ allele express itself fully/ completely. Denoted by Capital letter. It can express itself in both homozygous and heterozygous condition.

Recessive : (t, r, w etc)

-          The character / allele is suppressed and can’t express itself in single condition. It can only expressed in homozygous condition.

Wild allele :

The dominant allele originally present in Population.

Homozygous condition : (TT, tt, RR etc)

-          Similar alleles present on corresponding locus of Homologous chromosome.

Heterozygous condition : (Tt, Rr, Ww etc)

-          Dissimilar alleles present on corresponding locus of homozygous chromosome.

Hemizygous:

-          If only one gene of a pair is present, Its called hemizygous condition.  (Male individual – hemizygous for sex linked gene XY)

Gamete :

-          Haploid (n) Sex cells (e.g- sperm / egg)

Pure line :

-          If only one type of pure offspring present.

Parent : mating generation

Off spring : next generation of parent

F1 generation - First generation of offspring / 1st Filial Generation. (Bateson 1905)

Wild /pure – With original genotype and phenotype

Hybrid / recombinant –  With mixed genotype and phenotype.

Hybrid Vigour or Heterosis:

-              The superior hybrid individual over either of its parent (in any trait/ traits).

Inbreeding :

 When the individuals of a progeny (e.g. F1 generation) are allowed to cross with each other, it is called inbreeding.

Monohybrid cross :

 The cross between two parents differing in a single pair of contrasting characters is called monohybrid cross and the F1 offspring as the hybrid.

 Monohybrid ratio :

The phenotypic ratio of 3 dominants : 1 recessive obtained in the F2 generation from the monohybrid cross is called monohybrid ratio.

Dihybrid cross :

The cross between two parents in which two pairs of contrasting characters are studied simultaneously.

Poly Hybrid cross:

    Involvement of more than 2 allelic pairs (contrasting characters).

Back Cross :

    The cross of an individual with any of its parent (Previous generation).

Out Cross :

     When F1 offspring (heterozygous) crossed with Dominant parent.

Test cross :

    The cross of F1 offspring (Heterozygous having dominant genotype)  with its recessive parent.

Reciprocal Cross:

A cross in which 2 parents are same , but in one experiment X can be used as male and Y as female, in another experiment Y as male and X as female.

Punnett Square :

    A checker board invented by- RC Punnett to show the result of a cross between two individual. Male gametes lie horizontally and female gametes lie vertically.

Gene Pool :

    Sum total of all genotype of all organisms, in a population.

 

 

 

Gregor Johann Mendel ( Father of Genetics)

Name: Johann Mendel

Mendel

Born: July 20, 1822

Died: January 6, 1884

Education: University of Olomouc, University of Vienna

 

    Gregor Mendel, is the "father of genetics," was born in Austria in 1822. Mendel (was a monk) discovered - basic principles of heredity through experiments. (in monastery's garden - the inheritance of certain traits/ characters in pea plants follows particular patterns )

     Mendel was born on July 20, 1822 was in Heinzendorf, Austria. He sent to school in Troppau to continue his secondary education at the Age 11. In 1840, he graduated from the school with honors.

    After graduation, A two-year program at the Philosophical Institute of the University of Olmütz. in the subjects of physics and math. Mendel graduated in 1843.

    That same year, Mendel began studying to be a monk: He joined the St. Thomas Monastery in Brno, ( given the name Gregor).

    In 1851, he went to the University of Vienna, to continue his studies in the sciences. Mendel studied mathematics and physics under Christian Doppler, studied botany under Franz Unger,

    In 1853, after completing his studies at the University of Vienna, Mendel returned to the monastery in Brno - took a teaching position at a secondary school.

Experiments :

 

Around 1854, Mendel began his research. Mendel’s research continued over as many as eight years (between 1856 and 1863). It was involved tens of thousands of individual plants.

-          Mendel chose to peas for his experiments for many distinct varieties, and because offspring could be quickly and easily produced.

-          Then  cross-fertilized pea plants of opposite characteristics—tall with short, smooth with wrinkled,  

-          Then he put forth the theory that all living things have traits and factor.

In 1865, Mendel delivered - his findings to the Natural Science Society in Brno, the results of his studies published in their journal - " Experiments on Plant Hybrids". (same year)

But Mendel’s work was ignored. Mendel did little to promote his work.

Mendel's finding was not accepted as being generally applicable.

Later Life and Death:

 

In 1868, Mendel taught for 14 years, and gradually failing eyesight. Gregor Mendel died on January 6, 1884, at the age of 61. Mendel’s research remains buried to decade. His 8 years (1856- 1865) of experimental knowledge remain unknown to the world.

1900: Rediscovery :

-          De Vries, Correns and Tschermak independently rediscover Mendel's work.


-          3 botanists - Hugo De Vries, Carl Correns and Erich vonTschermak - independently rediscovered Mendel's work in the same year (1900).

-          The three Europeans were unknown to each other.

-          They were working on different plant hybrids and the laws of inheritance.

-           When they reviewed the literature before publishing their own results, find Mendel's old papers.

By 1900, people were sufficiently understood to give Mendel's abstract ideas as a physical context. He was awarded as “Father of Genetics”.


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https://uksirnotes.blogspot.com/2021/06/chse-biology-syllabus-uksir.html

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